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Multi-component reaction between aromatic aldehyde, ethyl acetoacetate and urea catalyzed by Brönsted ionic liquid under microwave irradiation

Hai Truong Nguyen 1
Nguyen Thi Thanh Huynh 1
Phuong Hoang Tran 1, *
  1. University of Science, VNU-HCM
Correspondence to: Phuong Hoang Tran, University of Science, VNU-HCM. Email: pvphuc@vnuhcm.edu.vn.
Volume & Issue: Vol. 2 No. 3 (2018) | Page No.: 68-77 | DOI: 10.32508/stdjns.v2i3.755
Published: 2019-05-23

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This article is published with open access by Viet Nam National University Ho Chi Minh City, Viet Nam. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

Abstract

[(SO3H)4C4C1Im]HSO4 is a Brönsted ionic liquid, which was found to be an effective catalyst for organic synthesis. Ionic liquid was prepared from 1-methylimidazole and 1,4- butanesultone (ratio = 1:1), structure of [(SO3H)4C4C1Im]HSO4 was characterized by using nuclear magnetic resonance NMR spectroscopy and high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS). Ionic liquid was used as a catalyst for multi-component reaction, which afforded the desired products in high yields (over 80%) and short reaction time (5 min) under microwave irradiation. The catalyst could be recycled several times without loss of efficient catalytic activity.

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