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VNUHCM Journal of

Advanced Research in Natural Sciences

An official journal of Viet Nam National University Ho Chi Minh City, Viet Nam

ISSN: 3126-3011
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Ultrasound-accelerated arylthiomethylation of indole via multicomponent reaction in water catalyzed by acetic acid

Thi Thi Xuan Luu 1, *
Vinh Quang Pham 2

  1. University of Science, VNU-HCM
  2. Le Hong Phong upper secondary school-Dong Nai
Correspondence to: Thi Thi Xuan Luu, University of Science, VNU-HCM. Email: Nghiado@sci.edu.vn.
Volume & Issue: Vol. 1 No. T1 (2017) | Page No.: 80-85 | DOI: 10.32508/stdjns.v1iT1.442
Published: 2017-03-31

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Copyright © 2018 by the author(s).

This article is published with open access by Viet Nam National University Ho Chi Minh City, Viet Nam. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

Abstract

Multicomponent reactions (MCRs) play an important role to create the molecular complexity in a one-step process. Based on the mechanism and process of Mannich-type reactions in the synthesis of Grammin, arylthiomethylation reactions of indole were performed by using three components: indole, p-thiocresol and a solution of formaldehyde (36%) under two activation conditions, e.g. magnetic stirring and ultrasonic irradiation. The main product, 3-(p-tolylthiomethyl)-1H-indole, was obtained in a moderate yield (54%) under short irradiation (40 minutes) by probe sonicator.

Keywords: arylthiomethylation ultrasound irradiation acetic acid indole

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